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GHB (gamma-hydroxybutyrate) is a central nervous system (CNS) depressant Some people dye their G blue with food coloring in order to distinguish it from .GHB. Profile. The chemical gamma-hydroxybutyrate (GHB) is a naturally occurring component of human cells. It is a central nervous depressant that was initially .GHB is used therapeutically and recreationally, although the precise mechanism of action responsible for its different behavioral effects is not entirely clear.There are distinct differences in the accessibility, purity, dosing, and misuse associated with illicit gamma-hydroxybutyrate (GHB) compared to pharmaceutical .Gamma-hydroxybutyric acid, or GHB, is a substance naturally present within (n = 24) were in the range 0.5 to 12.0 ng/mg, with no influence due to hair color.